Abstract. Cladocerans are microcrustaceans component of the zooplankton in a wide array of aquatic ecosystems. These organisms, in particular the genus Daphnia, have been widely used model organisms in studies ranging from biomedical sciences to ecology. Here, we present an overview of the contribution of studies with cladocerans to understanding the consequences at different levels of biological organization of stress induced by environmental factors. We discuss how some characteristics of cladocerans (e.g., small body size, short life cycles, cyclic parthenogenesis) make them convenient models for such studies, with a particular comparison with other major zooplanktonic taxa. Then we illustrate the contribution of cladocerans to stress research with examples encompassing stress responses spanning from the molecular to the populational level. Most worth of note are recent studies that presented evidence of beneficial consequences of mild stress caused by natural stressors (cross-tolerance), which may be passed along across generations, favoring individual survival and species persistence in fluctuating environments. This would be particularly relevant for environments prone to frequent natural environmental fluctuations, such as coastal lagoons and other shallow aquatic ecosystems. Based on reviewed studies, a conceptual model is presented summarizing the potential effects of a first stressor on the organism's resistance to a second one. We finish by highlighting some gaps on environmental stress research that could benefit from further studies using cladocerans as model organisms.