Resumo. Excessive exposure of human to organic contaminants from industrial effluents calls for the implementation of effective pollutants removal techniques. This article investigates the photocatalytic degradation of bromophenol blue dye using Strontium oxide nanoparticles co-doped with Nickel and Zinc. Hydrothermal synthesis produced the nanoparticles, which were subsequently characterized using various analytical techniques. UV/Visible revealed absorption peaks at 294 nm, 306 nm, 311 nm, and 318 nm, while FTIR spectroscopy identified stretching peaks at 416 cm-1, 588 cm-1, and 856 cm-1 for Ni-O and Sr-O bonds. The nanoparticles displayed diameters ranging from 30.50 nm to 36.97 nm. EDX analysis confirmed the elemental composition, with Sr and O comprising of approximately 82.02 %, and Ni and Zn approximately 3.21%. Photocatalytic degradation experiments demonstrated that SrO nanoparticles 85.42% degradation efficiency, while co-doped SrO nanoparticles achieved an impressive 97.97% degradation efficiency. This work highlights the potential co-doped SrO nanoparticles as a promising solution for the efficient removal of organic pollutants from the industrial wastewater, addressing environment contamination concerns.