Resumo. ABSTRACT The literature has shown an increased prevalence of common mental disorder over the years, especially among women. Carrying out population surveys to investigate the prevalence of psychological morbidity and associated factors are relevant, allowing early identification of cases to suggest and/or forward to appropriate intervention strategies. This study aimed to estimate the prevalence of common mental disorders (CMD) and verify its relationship with physical activity levels (PAL), body mass index (BMI) and economic / demographic variables in adult and elderly women in Uberaba, Minas Gerais. The population sample (multistage and probabilistic) consisted by 1520 women. Data collection was carried out through home interviews. For investigation of the CMD it was used the Self-Report Questionnaire; the PAL was measured by long version of the International Physical Activity Questionnaire; to calculate BMI it was measured height and weight. The prevalence of CMD was 29.67%, no significant associations with PAL and BMI. On the other hand, CMD was associated with economic disadvantages (low income and low education) and sociodemographic questions (married and not to be the head of family).