Resumo. The study aimed to obtain statistical models to estimate the equilibrium moisture content of OSB panels as a function of temperature and relative humidity of air, as well as evaluate the effect of some production variables on the equilibrium moisture content of the panels. The experimental design consisted of six processing conditions, three air temperature and six relative humidity of air. In the processing conditions, were evaluated three different thicknesses of the strand particles (0.4, 0.7 and 1.0 mm), two apparent densities of panels (0.65 and 0.90 g/cm³) and three levels of pressure in the pressing of the panels (40, 60 and 80 kgf/cm²). For each treatment four panels were produced with the wood of Pinus taeda and 6% of phenol formaldehyde adhesive. In the evaluation of the experiment was considered a completely randomized design arranged in a factorial triple 6 x 6 x 3, in order words, six production variables (processing conditions), three air temperatures (30, 40 and 50°C) and 6 relative humidity (40, 50, 60, 70, 80, 90%). The means were compared statistically by Scott-Knott test at the 5% level of significance. The modeling the equilibrium moisture content of OSB panels was performed with fit the multiple polynomial models for each treatment. Based on measurements of accuracy and the results can be concluded that: 1) it is recommended to use the model UEQ = β0 + β1UR + β2UR² + β3UR³ + β4Temp + ε for indirect estimation of equilibrium moisture content of OSB panels 2) The temperature shows linear influence on the equilibrium moisture content of the panels, while the relative humidity of air shows behaving of third order polynomial, and the relative humidity of air affects more pronouncedly the equilibrium moisture content of OSB panels than the ambient temperature; 3) In respect of the effect of production variables, the pressing of pressure of 80 kgf/cm² and the increased the thickness of the strand particles to 1.0mm thick promoted trend of reductions in average of the equilibrium moisture content of OSB panels. But the increased density of the panel promoted the trend of increasing of equilibrium moisture content of OSB panels; and 4) The use of multiple polynomial models allows that are produced contours to obtain the values of equilibrium moisture content of OSB as a function of relative humidity and temperature of the place where the panel is exposed, standing out for its convenience of use.